Abstract
Potent and selective inhibitors of Dyrk1B kinase were developed to explore the hypothesis, based on siRNA studies, that Dyrk1B may be a resistance mechanism in cells undergoing a stress response.
MeSH terms
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Animals
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COS Cells
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Cell Line, Tumor
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Chlorocebus aethiops
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Drug Discovery
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Drug Resistance
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Dyrk Kinases
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Humans
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MAP Kinase Kinase Kinases / antagonists & inhibitors
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MAP Kinase Kinase Kinases / metabolism
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Models, Molecular
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Protein Kinase Inhibitors / chemistry*
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Protein Kinase Inhibitors / pharmacokinetics
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Protein Kinase Inhibitors / pharmacology*
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Protein Serine-Threonine Kinases / antagonists & inhibitors*
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Protein Serine-Threonine Kinases / chemistry
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Protein Serine-Threonine Kinases / genetics
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Protein Serine-Threonine Kinases / metabolism
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Protein-Tyrosine Kinases / antagonists & inhibitors*
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Protein-Tyrosine Kinases / chemistry
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Protein-Tyrosine Kinases / genetics
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Protein-Tyrosine Kinases / metabolism
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RNA Interference
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RNA, Small Interfering / genetics
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Rats, Wistar
Substances
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Protein Kinase Inhibitors
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RNA, Small Interfering
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Protein-Tyrosine Kinases
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Protein Serine-Threonine Kinases
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MAP Kinase Kinase Kinases